The new ISDS rules regarding eye exams, DNA CEA testing as of June 1, 2013

I wrote to the ISDS and they promptly wrote me back. If you didn't know as of June 1, 2013, the dogs need to have the DNA CEA testing done and forwarded to the ISDS for the litter to be registered. I have the info that the ISDS sent me. Additionally I added a list of questions and their answers below. I am still asking more questions and when I get those answers, I will post them as well.

Eye Examinations and ISDS Rules

News from the Carlisle Meetings – January 2013

DNA CEA - Before any progeny are to be registered, the sire and dam must have been DNA CEA tested. Results of the tests must be the original DNA CEA result and vet submission form, forwarded on to the ISDS Office.

This rule takes effect from 1^st June 2013.

An ophthalmic test is recommended where the sire/dam is involved in producing 2 or more litters and the sire/dam is over the age of 2 years. It is important that ophthalmic tests continue for all dogs to ensure eye diseases are detected.

MICROCHIPPING - With immediate effect, all puppies must be microchipped before registration.

 Note – For National Trial entry:

·     Dogs registered before 1 June 2013 - an ophthalmic test is required in the absence of a DNA CEA test.

·     Dogs registered after 1 June 2013 - an ophthalmic test is not required.

 Further information can be found on the Society website www.isds.org.uk  “How Examination under the BVA/KC/ISDS Eye Scheme can help you and your breed” – article by Professor Sheila Crispin

Additional material “DNA Testing for Inherited eye diseases in Border Collies”.

Optigen

Optigen give details of a number of clinics organised, you can find information on their website www.optigen.com and select ‘Clinic Schedule’.

IDEXX

Idexx provide information for vets -  www.idexx.co.uk

 My questions to the ISDA. Questions in red, answers in italics

If the DNA CEA results are dam is  Normal and sire is  Carrier, and the pups can be registered?

Existing registration rules apply: Yes the pups can be registered (one parent Normal and other parent Carrier), each pup must have a microchip and a statement will appear on their Certificate declaring the DNA CEA status of the parents. 

If the pup is to be bred, the pup will have to have a DNA CEA test done?  (are dam is Normal and sire is  Carrier)

Yes the pup will need a DNA CEA test before future breeding. 

What is one of the results is affected and one is Normal? Sire is affected, dam is Normal?

Existing registration rules apply:  If a dog is CEA Affected following an ophthalmic examination and either of its parents has only an ophthalmic pass then that parent is immediately barred from the registration of further matings until it is DNA CEA tested.  A dog diagnosed at an ophthalmic examination as being affected by PRA may not have any further progeny registered. 

There are only two pairings normally permitted to breed under the DNA CEA rules.  That is, one parent must be DNA CEA Normal and the other parent may be DNA CEA Normal or Carrier.  Breeding from CEA Affected dogs is prohibited except where the dog is of exceptional merit (of genetic benefit) then an appeal may be made to the Stud Book Committee for permission to breed with a DNA CEA Normal dog. 

If two carriers are bred, then what happens?
Mating two carrier parents is not permitted.  If one is a Carrier then it should only be mated with a DNA CEA Normal dog. 

If both parents are found to be carriers during the transition period, then the puppy registration folder would need to be approved by the Stud Book Committee.  If the Stud Book Committee approve the registration of the litter then all pups would need to be microchipped and the pups certificates will be marked with the carrier status of both parents and those pups will also need a DNA CEA tested before future breeding.  Some of the litter could be affected by CEA which should be picked up at an ophthalmic test.  If the pups are affected by CEA at an ophthalmic test or DNA test, they will be prohibited from breeding. 

What if one of the results is affected and one is carrier? Sire is affected and dam is Carrier?
Existing registration rules apply:  If a dog is CEA Affected following an ophthalmic examination and either of its parents has only an ophthalmic pass then that parent is immediately barred from the registration of further matings until it is DNA CEA tested.  A dog diagnosed at an ophthalmic examination as being affected by PRA may not have any further progeny registered. 

There are only two pairings normally permitted to breed under the DNA CEA rules.  That is, one parent must be DNA CEA Normal and the other parent may be DNA CEA Normal or Carrier.  Breeding from CEA Affected dogs is prohibited except where the dog is of exceptional merit (of genetic benefit) then an appeal may be made to the Stud Book Committee for permission to breed with a DNA CEA Normal dog. 

Is the June 1^st date the actual mating date or birth of pups date?

After the 1^st June, 2013 any mating card will be processed but both the sire and dam owner must ensure we receive the DNA CEA test result and vet sample submission form before puppy registration. If a puppy folder is received in the office, it will be held until we receive the DNA CEA test results. 

What is sire/dam have had the DNA CEA done, for example two years ago and a pup from that litter (Both parents were Normal), “Moss” is now two years old and cleared “NORMAL” by parentage, and then breed to a bitch on June 2, 2013? Will he have to be re-tested or is he clear by parentage? (Ignore the breeding bitch in this example)
New rule from 1^st June, 2013: Each breeding dog will require a DNA CEA test in its own right; an inherited status will not be accepted.   

What is sire/dam have had the DNA CEA done, for example two years ago and a pup from that litter (one parent was Normal and one was CARRIER), “Moss” has not been tested and then breed to a bitch on June 2, 2013? Will he have to be re-tested? (Ignore the breeding bitch in this example)
“Moss”needs one DNA CEA test in his own right if he is bred from after 1^stJune, 2013, registration rules apply as normal. If he was DNA CEA tested before 1^st June, 2013 then the existing result will be used and a further DNA CEA test will not be required.

What if a mating was done and one parent was not tested. Will the papers be on hold until the parent is done?

After 1^st June, 2013 registration will not progress until we have a DNA CEA test result for each parent.  

What if the owner of the untested bitch of the litter (for this example) refuses to do the DNA CEA test? Can the pups be tested and if (Normal or Carrier) then be registered?

Again this case would need to be considered by the Stud Book Committee.

What if a mating was done and one parent was not tested (and the ISDS per the rules does not register the pups) . Can one of the pups be tested and the result is Normal, how does one get the pup registered?

After 1^st June, 2013 registration will not progress until we have a DNA CEA test result for each parent. Same as 6) above, the pup cannot be registered unless we have the parents results.

What if the owner of the untested bitch of the litter (for this example) refuses to do the DNA CEA test? Can the pups be tested and if (Normal or Carrier) then be registered? Or will all the pups be unable to be registered? Can a pup be ROM?

A Registration On Merit is for dogs of exceptional working standard over the age of 2 years. ROM’s now cost £500 but require the DNA CEA test and ophthalmic test but also need to pass a working test or have gained points at trials.

Why do we have to do the DNA CEA test if BOTH parents were normal and the now the pups are clear by parent heritage? What is the reasoning behind this?

Having checked your question with our Chief Executive, National Presidents and Chairman, they have confirmed that an inherited Normal DNA status is not acceptable for breeding. By testing each breeding dog in its own right we will have a much clearer picture of the pattern of Normal, Carrier and Affected status. This will ensure that our data is accurate but also will be helpful where accidental matings may occur either with or without a breeders knowledge.